This article will explain the differences between selamectin & ivermectin. Which one should you choose for your home? Read on to learn more! Hopefully, this will help you decide which is better for your family! You’ll be glad that you did. Here’s a look at the pros and cons of each treatment. The two drugs share a similar mechanism of action, despite their different uses.
In vivo studies showed similar dermal penetration of ivermectin to selamectin. Selamectin was found to accumulate in the brain far less than ivermectin. Selamectin concentrations in brain tissue were seven times higher in mice with mdr1-/ knockout, and three times higher than those of control-/ mice.
Laboratory tests show that selamectin accumulates in the brain less than ivermectin. It accumulates to a greater degree in the brain of MDR1-/-mutant mice without causing neurotoxicity. However, selamectin has a lower therapeutic margin in MDR1-mutant mice than ivermectin.
In dogs, ivermectin is most commonly used as a heartworm preventive. It can also be used off-label for mites, capillaries, and ear mites. It can also be used in combination with other medications to deworm. It is available as chewable tablets, topical liquid, or as an injection.
Both drugs offer significant benefits in the treatment of mites. However, selamectin poses significant risks due to its effects on central nervous system. Selamectin blocks the parasite’s signaling cells by binding to GABA receptors in our nervous system. This results in the mite being killed. This is why selamectin does not work as well as ivermectin for mite infestations in dogs.
Despite the similarities in the way these two treatments work, ivermectin is more likely to cause poisoning in dogs and cats than selamectin. The latter is safer for pregnant or lactating rats and the application of selamectin to the skin is more gentle than injectable medication. To ensure that the animal’s skin is completely dry, wait at least 30 minutes after bathing.
Studies have shown that CreER recombinases are affected by ivermectin in offspring. The study did not propose any specific mechanism, but it did show that ivermectin and selamectin both stimulate CreER. Moreover, the metabolites of both drugs can be transmitted to offspring via the mother’s milk.
Selamectin is highly effective against demodectic mange mites. Selamectin is readily absorbed through the skin and circulates throughout the bloodstream. Its concentration is high in the sebaceous glands and is also secreted into the intestine. Both treatments are endectocidal, which means that they kill nematodes.
Although both ivermectin and selamectin are effective in controlling flea infestations, the former is more effective in preventing and eliminating intestinal worms. Some breeds of dog have a high MDR1 mutation, which increases the risk that ivermectin can penetrate the brain. They can be safely administered to dogs that are not sensitive at therapeutic doses.